ARCIMBOLDO: Crystallographic Ab Initio protein solution far below atomic resolution

Dayte D. Rodríguez Martínez, Christian Grosse, Sebastian Himmel, César González, Iñaki M. de Ilarduya, Stefan Becker, George M. Sheldrick and Isabel Usón. Nature Methods 6(9): 651-653 (2009)

Ab Initio macromolecular phasing has been so far limited to small proteins at atomic resolution (1.2Å or better unless heavy atoms are present). We present a general method for 2Å data, based on combination of location of model fragments like small α-helices with PHASER (currently only version 2.1.4 supported) and density modification with SHELXE, distributed over a grid of computers running CONDOR.
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"Crystallographic ab initio protein structure solution below atomic resolution"
Dayté D Rodríguez, Christian Grosse, Sebastian Himmel, César González, Iñaki M de Ilarduya, Stefan Becker, George M Sheldrick & Isabel Usón
Published online: 16 August 2009 | doi:10.1038/nmeth.1365

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